Patient Education: Low Dose Naltrexone
What is Low Dose Naltrexone (LDN)?
Low Dose Naltrexone (LDN) is a medication used in smaller doses than the standard naltrexone prescription. While full-dose naltrexone is typically prescribed to manage alcohol or opioid dependence, LDN is used for a variety of off-label purposes, including:
Autoimmune diseases (e.g., multiple sclerosis, rheumatoid arthritis)
Chronic pain conditions (e.g., fibromyalgia)
Inflammatory conditions (e.g., Crohn’s disease)
Neuropathic pain
Important: LDN is not FDA-approved for these conditions but has been studied and used off-label due to its potential benefits in reducing inflammation, modulating the immune system, and relieving pain.
Endorphin Boost: LDN temporarily blocks opioid receptors, prompting the body to produce more endorphins, which can improve mood, reduce pain, and support immune function.
Immune Modulation: LDN helps regulate the immune system, potentially reducing inflammation and autoimmunity.
Anti-inflammatory Effects: LDN may reduce inflammatory markers in certain conditions, leading to symptom improvement.
Dose: LDN is typically started at a low dose (e.g., 0.5 to 1.5 mg) and gradually increased to 4.5 mg or as prescribed by your healthcare provider.
Timing: It is usually taken at bedtime, as it may align with the body’s natural endorphin production cycle.
Form: LDN may be compounded into capsules, liquid, or cream by a compounding pharmacy.
Note: Results may vary. Some patients notice improvement within weeks, while for others, it may take months.
LDN is generally well-tolerated, but some patients may experience:
Important: These side effects are typically mild and short-lived.
What Should I Tell My Doctor?
Inform your healthcare provider if you:
Are taking opioid medications (LDN should not be used with opioids as it can block their effects)
Are pregnant, breastfeeding, or planning to become pregnant
Have liver or kidney issues
Follow-up: Regular follow-up with your healthcare provider is essential to monitor your progress and adjust the dose as needed.
Avoid Alcohol and Opioids: Do not combine LDN with alcohol or opioids, as it may interfere with the medication's effects.
Storage: Store LDN in a cool, dry place, away from direct sunlight and out of reach of children.
When Should I Call My Doctor?
Contact your healthcare provider if you experience:
Severe or persistent side effects
New or worsening symptoms
Allergic reactions, such as rash, swelling, or difficulty breathing
1. Is LDN safe for long-term use?
Research suggests that LDN is safe for long-term use under medical supervision.
2. Can I take LDN with my current medications?
Discuss all medications and supplements with your healthcare provider to avoid interactions.
3. How soon will I see results?
Results vary by individual and condition. Be patient and consistent with your treatment.
